The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan

  title={The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan},
  author={Marta Gonz{\'a}lez-Freire and Gabriel Rodr{\'i}guez-Romo and Catalina Santiago and Natalia Bustamante-Ara and Thomas Yvert and F{\'e}lix G{\'o}mez-Gallego and Jos{\'e} Antonio Serra Rexach and Jonatan R. Ruiz and Alejandro Luc{\'i}a},
We studied the A55T, E164K, I225T, K153R and P198A variants in the myostatin (GDF8) gene, muscle strength and mass, and physical function during daily living in 41 nonagenarians [33 women, age range, 90, 97]. No participant carried a mutant allele of the aforementioned variants, except three participants (all women), who carried the R allele of the K153R polymorphism, with one of them (woman aged 96 years) being homozygous. Overall, in KR women muscle phenotype values (1RM leg press and… CONTINUE READING

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