The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan

@article{GonzlezFreire2010TheKV,
  title={The K153R variant in the myostatin gene and sarcopenia at the end of the human lifespan},
  author={Marta Gonz{\'a}lez-Freire and Gabriel Rodr{\'i}guez-Romo and Catalina Santiago and Natalia Bustamante-Ara and Thomas Yvert and F{\'e}lix G{\'o}mez-Gallego and Jos{\'e} Antonio Serra Rexach and Jonatan R. Ruiz and Alejandro Luc{\'i}a},
  journal={AGE},
  year={2010},
  volume={32},
  pages={405-409}
}
We studied the A55T, E164K, I225T, K153R and P198A variants in the myostatin (GDF8) gene, muscle strength and mass, and physical function during daily living in 41 nonagenarians [33 women, age range, 90, 97]. No participant carried a mutant allele of the aforementioned variants, except three participants (all women), who carried the R allele of the K153R polymorphism, with one of them (woman aged 96 years) being homozygous. Overall, in KR women muscle phenotype values (1RM leg press and… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Explore Further: Topics Discussed in This Paper

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

Sarcopenic obesity: how do we treat it?

Current opinion in endocrinology, diabetes, and obesity • 2013

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Does the K 153 R variant of the myostatin gene influence the clinical presentation of women with McArdle disease

W Huygens, MA Thomis, +4 authors G Beunen
2009

Genotype distributions in top-level soccer players: a role for ACE?

International journal of sports medicine • 2009
View 2 Excerpts

Comorbidity and 1-year mortality risks in nursing home residents.

Journal of the American Geriatrics Society • 2005
View 1 Excerpt

Characterization and identification of the inhibitory domain of GDF-8 propeptide.

Biochemical and biophysical research communications • 2004
View 3 Excerpts

Similar Papers

Loading similar papers…