The K+/Cl− co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation

Abstract

GABA (γ-aminobutyric acid) is the main inhibitory transmitter in the adult brain, and it exerts its fast hyperpolarizing effect through activation of anion (predominantly Cl−)-permeant GABAA receptors. However, during early neuronal development, GABA A-receptor-mediated responses are often depolarizing,, which may be a key factor in the control of several… (More)
DOI: 10.1038/16697

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