The Journal of Obstetrics and Gynecology of India

  title={The Journal of Obstetrics and Gynecology of India},
  author={Khalīl and Pandya},
  • Khalīl, Pandya
  • Published 2006
  • In 1866 J Langdon Down made the observation of a subgroup of patients with particular facial features and mental handicap in the outpatient department of the London Hospital 1. In the late 1950’s, it was shown that an extra acrocentric chromosome was present in persons with Down syndrome, resulting in a diploid chromosome number of 47. It is now known that Down syndrome results when either the whole or a segment of the long arm of chromosome 21 is present in three copies instead of two (Table 1… CONTINUE READING

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