The Jejunum of Diarrhea-Predominant Irritable Bowel Syndrome Shows Molecular Alterations in the Tight Junction Signaling Pathway That Are Associated With Mucosal Pathobiology and Clinical Manifestations

@article{Martinez2012TheJO,
  title={The Jejunum of Diarrhea-Predominant Irritable Bowel Syndrome Shows Molecular Alterations in the Tight Junction Signaling Pathway That Are Associated With Mucosal Pathobiology and Clinical Manifestations},
  author={C Martinez and Mar{\'i}a Vicario and Laura Ramos and Beatriz Lobo and J. L. Mosquera and C. Vaquerizo Alonso and {\`A}. Mediavilla S{\`a}nchez and Mar Guilarte and Mar{\'i}a Antol{\'i}n and In{\'e}s M. de Torres and Ana Mar{\'i}a Gonz{\'a}lez-Castro and Marc Pigrau and Esteban Saperas and Fernando Azpiroz and Javier F Santos},
  journal={The American Journal of Gastroenterology},
  year={2012},
  volume={107},
  pages={736-746}
}
OBJECTIVES:Diarrhea-predominant irritable bowel syndrome (IBS-D) patients show altered epithelial permeability and mucosal micro-inflammation in both proximal and distal regions of the intestine. The objective of this study was to determine the molecular events and mechanisms and the clinical role of upper small intestinal alterations.METHODS:Clinical assessment and a jejunal biopsy was obtained in IBS-D patients and healthy subjects. Routine histology and immunohistochemistry was performed in… CONTINUE READING
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Impaired intestinal integrity in the colon of irritable bowel syndrome patients: involvement of soluble mediators

  • P Aubert
  • Gut
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