The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression.

@article{Radtke2005TheJS,
  title={The Jak1 SH2 domain does not fulfill a classical SH2 function in Jak/STAT signaling but plays a structural role for receptor interaction and up-regulation of receptor surface expression.},
  author={Simone Radtke and Serge Haan and Angela J{\"o}rissen and Heike M Hermanns and Sandra Diefenbach and Tanya Smyczek and Hildegard Schmitz-Vandeleur and Peter Claus Heinrich and Iris Behrmann and A. M. J. den Haan},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 27},
  pages={
          25760-8
        }
}
The presence of a Src homology 2 (SH2) domain sequence similarity in the sequence of Janus kinases (Jaks) has been discussed since the first descriptions of these enzymes. We performed an in depth study to determine the function of the Jak1 SH2 domain. We investigated the functionality of the Jak1 SH2 domain by stably reconstituting Jak1-defective human fibrosarcoma cells U4C with endogenous amounts of Jak1 in which the crucial arginine residue Arg466 within the SH2 domain has been replaced by… CONTINUE READING
Highly Cited
This paper has 83 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

84 Citations

051015'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 84 citations based on the available data.

See our FAQ for additional information.