The Jak-STAT pathway.

@article{Imada2000TheJP,
  title={The Jak-STAT pathway.},
  author={Keisuke Imada and Warren J Leonard},
  journal={Molecular immunology},
  year={2000},
  volume={37 1-2},
  pages={
          1-11
        }
}
A variety of important cellular functions are regulated by cytokines. The Jak-STAT pathway is one of the important signaling pathways downstream of cytokine receptors. Following binding of a ligand to its cognate receptor, receptor-associated Jaks are activated. STAT proteins are then in turn activated by tyrosine phosphorylation by Jak kinases, allowing their dimerization and subsequent translocation into the nucleus, where they modulate expression of target genes. Indispensable functions of… CONTINUE READING
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