The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.

@article{Heim1996TheJP,
  title={The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.},
  author={Markus H Heim},
  journal={European journal of clinical investigation},
  year={1996},
  volume={26 1},
  pages={1-12}
}
  • Markus H Heim
  • Published 1996 in European journal of clinical investigation
The Jak-STAT pathway is a newly discovered intracellular signal transduction pathway that is used by a growing number of extracellular signalling proteins (ESPs) for transcriptional activation of target genes. Binding of ligands to their transmembrane receptors leads to activation of members of the Jak tyrosine kinase family. The activated receptor-kinase complexes recruit members of the STAT family and activate them by phosphorylation. As a consequence, the phosphorylated STAT proteins… CONTINUE READING
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