The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells.

@article{Dumler1998TheJP,
  title={The Jak/Stat pathway and urokinase receptor signaling in human aortic vascular smooth muscle cells.},
  author={I. L. Dumler and Angelika Weis and Oleg A Mayboroda and Christian Maasch and Uwe Jerke and Hermann Haller and Dietrich C. Gulba},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 1},
  pages={315-21}
}
The binding of urokinase plasminogen activator (uPA) to its specific receptor (uPAR) facilitates migration of vascular smooth muscle cells (VSMC). However, the signaling cascade utilized by the urokinase receptor is only incompletely understood. We investigated intracellular uPA/uPAR signaling in human aortic VSMC from the cell membrane to the nucleus. uPA binding to VSMC induced a rapid and pronounced increase in tyrosine phosphorylation of several proteins with molecular masses of 53-60, 85… CONTINUE READING