The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK.

@article{Willoughby2003TheJP,
  title={The JNK-interacting protein-1 scaffold protein targets MAPK phosphatase-7 to dephosphorylate JNK.},
  author={Emma A Willoughby and G. R. Perkins and Mary K. L. Collins and Alan J. Whitmarsh},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 12},
  pages={10731-6}
}
The c-Jun N-terminal kinase (JNK) group of mitogen-activated protein kinases (MAPKs) are activated by pleiotropic signals including environmental stresses, growth factors, and hormones. A subset of JNK can bind to distinct scaffold proteins that also bind upstream kinases of the JNK pathway, allowing sequential kinase activation within a signaling module. The JNK-interacting protein-1 (JIP-1) scaffold protein specifically binds JNK, MAP kinase kinase 7, and members of the MLK family and is… CONTINUE READING