The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes

  title={The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes},
  author={Huai Deng and Weiguo Zhang and Xiaomin Bao and Janine Nicole Martin and Jack R. Girton and J\orgen Johansen and Kristen M Johansen},
The JIL-1 kinase localizes to interband regions of Drosophila polytene chromosomes and phosphorylates histone H3 Ser10. Analysis of JIL-1 hypomorphic alleles demonstrated that reduced levels of JIL-1 protein lead to global changes in polytene chromatin structure. Here we have performed a detailed ultrastructural and cytological analysis of the defects in JIL-1 mutant chromosomes. We show that all autosomes and the female X chromosome are similarly affected, whereas the defects in the male X… CONTINUE READING
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