The JAZ family of repressors is the missing link in jasmonate signalling

@article{Chini2007TheJF,
  title={The JAZ family of repressors is the missing link in jasmonate signalling},
  author={Andrea Chini and Sandra Fonseca and G. Fern{\'a}ndez and Bruce A T Adie and Jos{\'e} Manuel Chico and Oscar Lorenzo and Gloria Garc{\'i}a-Casado and Irene L{\'o}pez-Vidriero and Francisca Mar{\'i}a Lozano and Mar{\'i}a Rosa Ponce and Jos{\'e} Luis Micol and Roberto Solano},
  journal={Nature},
  year={2007},
  volume={448},
  pages={666-671}
}
Jasmonates are essential phytohormones for plant development and survival. However, the molecular details of their signalling pathway remain largely unknown. The identification more than a decade ago of COI1 as an F-box protein suggested the existence of a repressor of jasmonate responses that is targeted by the SCFCOI1 complex for proteasome degradation in response to jasmonate. Here we report the identification of JASMONATE-INSENSITIVE 3 (JAI3) and a family of related proteins named JAZ… 
View on Nature
ncbi.nlm.nih.gov
1,824 Citations
Highly Influential Citations
190
Background Citations
783
Methods Citations
44
Results Citations
21

Figures from this paper

1,824 Citations

Citation Type

Citation Type

JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling
TLDR
The results suggest a model in which jasmonate ligands promote the binding of the SCFCOI1 ubiquitin ligase to and subsequent degradation of the JAZ1 repressor protein, and implicate theSCFCOi1–JAZ1 protein complex as a site of perception of the plant hormone JA–Ile.
The JAZ Proteins: A Crucial Interface in the Jasmonate Signaling Cascade
TLDR
Recent studies on the model plant Arabidopsis thaliana that provided essential and novel insights into JAZ proteins showed the value of protein–protein interaction studies to acquire fundamental insight into molecular signaling pathways.
JAZ4 is involved in plant defense, growth, and development in Arabidopsis.
TLDR
The findings suggest that JAZ4 participates in the canonical JA signaling pathway leading to plant defense response in addition to COI1/MYC-independent functions in plant growth and development, supporting the notion that Jaz4-mediated signaling may have distinct branches.
Arabidopsis Jasmonate Signaling Pathway
TLDR
A series of breakthroughs has identified the SCF, which consists of four subunits: a cullin, SKP1 (S-phase kinase-associated protein 1), a RING finger protein (RBX1/HRT1/ROC1, and an F-box protein) and the JASMONATE ZIM-DOMAIN proteins as central components in the perception of and transcriptional response to JA-Ile.
Repression of jasmonate signaling by a non-TIFY JAZ protein in Arabidopsis.
TLDR
It is shown that diverse plant species contain genes encoding putative non-TIFY JAZ proteins, including a previously unrecognized JAZ repressor in Arabidopsis (JAZ13, encoded by At3g22275), and that this expansion of the JAZ family allows fine-tuning of JA-mediated transcriptional responses.
JAZ repressors set the rhythm in jasmonate signaling.
Structural basis of JAZ repression of MYC transcription factors in jasmonate signaling
TLDR
Arabidopsis MYC3 undergoes pronounced conformational changes when bound to the conserved Jas motif of the JAZ9 repressor, which elucidate a dynamic molecular switch mechanism that governs the repression and activation of a major plant hormone pathway.
Molecular Rewiring of the Jasmonate Signaling Pathway to Control Auxin-Responsive Gene Expression
TLDR
The results showed that the modular components of JA signal transduction pathway can be artificially redirected to regulate auxin signaling pathway and control auxin-responsive gene expression.
THE ROLE OF ALTERNATIVE SPLICING IN THE REGULATION OF JASMONATE SIGNALING By
TLDR
The results show that the relative abundance of JAZ splice variants is not significantly affected by JA elicitation or tissue type, thus suggesting that alternative splicing of J AZ pre-mRNA is controlled by the efficiency with which cis-acting splice sites are selected by the spliceosome.
A Critical Role for the TIFY Motif in Repression of Jasmonate Signaling by a Stabilized Splice Variant of the JASMONATE ZIM-Domain Protein JAZ10 in Arabidopsis[C][W]
TLDR
It is shown that the conserved TIFY motif (TIFF/YXG) within the ZIM domain mediates homo- and heteromeric interactions between most Arabidopsis thaliana JAZs and suggests that the dominant-negative action of this splice variant involves protein–protein interaction through the Zim/TIFY domain.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 51 REFERENCES
JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling
TLDR
The results suggest a model in which jasmonate ligands promote the binding of the SCFCOI1 ubiquitin ligase to and subsequent degradation of the JAZ1 repressor protein, and implicate theSCFCOi1–JAZ1 protein complex as a site of perception of the plant hormone JA–Ile.
JASMONATE-INSENSITIVE1 Encodes a MYC Transcription Factor Essential to Discriminate between Different Jasmonate-Regulated Defense Responses in Arabidopsis
TLDR
The identification of several new loci involved in JA signaling and the characterization and positional cloning of one of them, JASMONATE-INSENSITIVE1 (JAI1/JIN1), a nuclear-localized basic helix-loop-helix-leucine zipper transcription factor whose expression is rapidly upregulated by JA, are described.
Jasmonate Signaling Pathway
TLDR
Progress in characterizing several new mutants augments the understanding of jasmonate signaling, and the Connections Map will be updated to include this new information.
The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis.
TLDR
It is demonstrated that COI1 associates physically with AtCUL1, AtRbx1, and either of the Arabidopsis Skp1-like proteins ASK1 or ASK2 to assemble ubiquitin-ligase complexes, which are designated SCF(COI1), and that the axr1 and coi1 mutations display a synergistic genetic interaction in the double mutant.
The COP9 signalosome interacts physically with SCF COI1 and modulates jasmonate responses.
TLDR
It is demonstrated using coimmunoprecipitation and gel-filtration analyses that endogenous as well as epitope-tagged COI1 forms SCF(COI1) and associates directly with CSN in vivo, and both COI 1 and CSN are essential for modulating the expression of genes in most cellular pathways responsive to JA.
COI1 links jasmonate signalling and fertility to the SCF ubiquitin-ligase complex in Arabidopsis.
TLDR
COI1 is expected to form a functional E3-type ubiquitin ligase in plants and to regulate expression of jasmonate responsive genes, possibly by targeted ubiquitination of a histone deacetylase.
Conserved MYC transcription factors play a key role in jasmonate signaling both in tomato and Arabidopsis.
TLDR
The results show that the JAMYC/AtMYC2 transcription factors function as members of a MYC-based regulatory system conserved in dicotyledonous plants with a key role in JA-induced defense gene activation.
Plant defense in the absence of jasmonic acid: The role of cyclopentenones
TLDR
It is concluded that the jasmonate family cyclopentenone OPDA regulates gene expression in concert with JA to fine-tune the expression of defense genes.
12-Oxo-Phytodienoic Acid Triggers Expression of a Distinct Set of Genes and Plays a Role in Wound-Induced Gene Expression in Arabidopsis1[w]
TLDR
Microarray analysis of Arabidopsis genes revealed that an OPDA signaling pathway functions independently of JA/MeJA signaling and is required for the wounding response inArabidopsis.
Arabidopsis CONSTANS-LIKE3 Is a Positive Regulator of Red Light Signaling and Root Growth[W]
TLDR
COL3 is identified as a positive regulator of photomorphogenesis that acts downstream of COP1 but can promote lateral root development independently of COP 1 and also function as a daylength-sensitive regulator of shoot branching.
...
1
2
3
4
5
...