The JAK2 exon 12 mutations: A comprehensive review

@article{Scott2011TheJE,
  title={The JAK2 exon 12 mutations: A comprehensive review},
  author={Linda M Scott},
  journal={American Journal of Hematology},
  year={2011},
  volume={86}
}
  • L. Scott
  • Published 1 August 2011
  • Biology
  • American Journal of Hematology
A variety of acquired mutations targeting JAK2 exon 12 are present in those patients with the myeloproliferative neoplasm, polycythemia vera, that lack the more common JAK2V617F mutation. Both mutation types perturb erythropoiesis, with individuals presenting with a raised hematocrit, reduced serum erythropoietin levels, and erythropoietin‐independent erythroid progenitor cells. However, there are also phenotypic differences that, until recently, precluded a significant proportion of patients… 
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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