The JAK-STAT pathway: impact on human disease and therapeutic intervention.

@article{OShea2015TheJP,
  title={The JAK-STAT pathway: impact on human disease and therapeutic intervention.},
  author={John J O'Shea and Daniella M Schwartz and Alejandro V Villarino and Massimo Gadina and Iain B. Mcinnes and Arian D J Laurence},
  journal={Annual review of medicine},
  year={2015},
  volume={66},
  pages={311-28}
}
The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway employed by diverse cytokines, interferons, growth factors, and related molecules. This pathway provides an elegant and remarkably straightforward mechanism whereby extracellular factors control gene expression. It thus serves as a fundamental paradigm for how cells sense environmental cues and interpret these signals to regulate cell growth… CONTINUE READING
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The JAK1-selective inhibitor GLPG0634 is safe and rapidly reduces disease activity in patients with moderate to severe rheumatoid arthritis; results of a 4-week dose ranging study

C Tasset, P Harrison, A Van der Aa
Arthritis Rheum. 65:S1018 • 2013
View 4 Excerpts
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Selective JAK1 inhibition in the treatment of rheumatoid arthritis: proof of concept with GLPG0634

F Vanhoutte, M Mazur, A Van der Aa
Arthritis Rheum • 2012
View 4 Excerpts
Highly Influenced

A phase 2 study of tofacitinib, an oral Janus kinase inhibitor, in patients with Crohn's disease.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association • 2014
View 1 Excerpt

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