The JAK-STAT pathway: impact on human disease and therapeutic intervention.

  title={The JAK-STAT pathway: impact on human disease and therapeutic intervention.},
  author={John J O'Shea and Daniella M Schwartz and Alejandro V Villarino and Massimo Gadina and Iain B. Mcinnes and Arian D J Laurence},
  journal={Annual review of medicine},
The Janus kinase (JAK)-signal transducer of activators of transcription (STAT) pathway is now recognized as an evolutionarily conserved signaling pathway employed by diverse cytokines, interferons, growth factors, and related molecules. This pathway provides an elegant and remarkably straightforward mechanism whereby extracellular factors control gene expression. It thus serves as a fundamental paradigm for how cells sense environmental cues and interpret these signals to regulate cell growth… CONTINUE READING
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