The JAK/STAT3 axis: A comprehensive drug target for solid malignancies.

Abstract

Intercellular communication between tumor cells, immune cells and the stroma characterises the tumor microenvironment, which is instrumental for establishing the ecological niche that fosters tumor growth and metastasis. While tumor cell intrinsic STAT3 signaling provides a crucial axis to support cell proliferation and survival, it also regulates many… (More)
DOI: 10.1016/j.semcancer.2017.06.001

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