The JAK/STAT signaling pathway.

  title={The JAK/STAT signaling pathway.},
  author={Jason S Rawlings and Kristin M Rosler and Douglas A. Harrison},
  journal={Journal of cell science},
  volume={117 Pt 8},
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. JAK activation stimulates cell proliferation, differentiation, cell migration and apoptosis. These cellular events are critical to… CONTINUE READING
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