The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster.

@article{Jinks2000TheJS,
  title={The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster.},
  author={Timothy Morgan Jinks and Alexandros D. Polydorides and Gretchen Calhoun and Paul Schedl},
  journal={Molecular cell},
  year={2000},
  volume={5 3},
  pages={581-7}
}
The choice of sexual identity in Drosophila is determined by a system that measures the X chromosome to autosome ratio (X/A). This system depends upon unequal expression of X-linked numerator genes in 1X and 2X nuclei. The numerators activate a special Sxl promoter, Sxl-Pe, in 2X/2A nuclei, but not 1X/2A nuclei. By multimerizing a conserved Sxl-Pe sequence block, we generated a gain-of-function promoter, Sxl-PeGOF, that is inappropriately active in 1X/2A nuclei. GOF activity requires the X… CONTINUE READING

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