The JAK/STAT pathway and Drosophila development.

  title={The JAK/STAT pathway and Drosophila development.},
  author={H Luo and Charles R. Dearolf},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={23 12},
The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila. Mutational analyses of these components have revealed a number of interesting developmental roles, and provide a mechanism to identify other interacting molecules and pathways. Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional… CONTINUE READING

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