The JAK/STAT pathway and Drosophila development

  title={The JAK/STAT pathway and Drosophila development},
  author={Hong Luo and Charles R. Dearolf},
The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila. Mutational analyses of these components have revealed a number of interesting developmental roles, and provide a mechanism to identify other interacting molecules and pathways. Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional… 

JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila

The general overview of JAK/STAT signaling in Drosophila is discussed with respect to its functions in the eye development and stem cell fate determination and its role in cell regulation during development and tumor formation.

The Hopscotch Jak kinase requires the Raf pathway to promote blood cell activation and differentiation in Drosophila

It is demonstrated that Hop requires the activity of the Raf pathway to promote the activation response of larval plasmatocytes, and evidence to suggest that the Hop and D-Raf proteins physically interact, and it is shown that basal level activity ofThe Raf pathway is required for the accumulation of circulating blood cells.


It is proposed that JAK/STAT and Hippo signaling pathways are integrated to control development of Drosophila by independently regulating the transcription of common target genes, such as CycE and E2f1 to control cell proliferation, and Diap1 to Control cell survival.

The endocytic control of JAK/STAT signalling in Drosophila

Domeless (Dome) is an IL-6-related cytokine receptor that activates a conserved JAK/STAT signalling pathway during Drosophila development. Despite good knowledge of the signal transduction pathway in

Signal transducer and activator of transcription proteins in leukemias.

Signal transducer and activator of transcription (STAT) proteins are a 7-member family of cytoplasmic transcription factors that contribute to signal transduction by cytokines, hormones, and growth

Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium

This work shows that activation in a gradient of the highly conserved JAK/STAT pathway is essential for orienting the cell rearrangement that drives elongation of a genetically tractable model.

The Drosophila STAT protein, stat92E, regulates follicle cell differentiation during oogenesis.

It is concluded that stat92E is necessary for the early differentiation of follicle cells and for proper germ line cell encapsulation during Drosophila oogenesis.



The JAK-STAT pathway in Drosophila.

Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway.

The unpaired (upd) gene is characterized, which displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (hopscotch) and STAT (stat92E) genes.

A Drosophila PIAS homologue negatively regulates stat92E

It is concluded that the correct dpias/stat92E ratio is crucial for blood cell and eye development.

Jaks and STATs: biological implications.

The Jak-STAT pathway is the focus of this chapter, a novel mechanism in which cytosolic latent transcription factors, known as signal transducers and activators of transcription (STATs), are tyrosine phosphorylated by Janus family tyrosin kinases (Jaks), allowing STAT protein dimerization and nuclear translocation.

Negative regulation of the JAK/STAT pathway

  • R. StarrD. Hilton
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 1999
The duration and intensity of a cell's response to cytokine appears to be determined by the net effect of several regulatory mechanisms, including receptor/ligand complex, JAK kinases, and STAT transcription factors.

A JAK-STAT pathway regulates wing vein formation in Drosophila.

Evidence is presented that the JAK-STAT signal transduction pathway regulates multiple developmental processes in Drosophila, and that the hopTum-1 and statHJ mutations can partially compensate for each other genetically, and Hop overexpression can increase D-Stat transcriptional activity in vitro, indicating that the gene products interact in a common regulatory pathway.

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway.

This review will examine how two receptor associated tyrosine kinases from the JAK family mediate the transduction of signal directly from receptor to nucleus.

Polarity determination in the Drosophila eye: a novel role for unpaired and JAK/STAT signaling.

Evidence is presented demonstrating that a localized source of the pathway ligand, Unpaired, is present at the midline of the developing eye, which is capable of activating the JAK/STAT pathway over long distances.

The Drosophila Jak kinase hopscotch is required for multiple developmental processes in the eye.

It is found that Hop is required for cell proliferation/survival in the eye imaginal disc, for the differentiation of photoreceptor cells, and for the establishment of the equator and of ommatidial polarity.