The J-curve in hypertension.

@article{Cruickshank2003TheJI,
  title={The J-curve in hypertension.},
  author={John Malcolm Cruickshank},
  journal={Current cardiology reports},
  year={2003},
  volume={5 6},
  pages={441-52}
}
The J-curve debate has continued for 25 years. Dependency upon observational and retrospective studies has confused the issue; only the full publication of data from the prospective, randomized Hypertension Optimal Treatment (HOT) study has thrown genuine light on the problem. Many examples of the J-curve relationship between blood pressure and cardiovascular/noncardiovascular events are due to reverse causality, where underlying disease (eg, poor left ventricular function, poor general health… CONTINUE READING

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