The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene

@article{Vidal1995TheIL,
  title={The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene},
  author={Silvia M Vidal and Michel L Tremblay and Gregory Govoni and Susan P Gauthier and Giovanna Sebastiani and Danielle Malo and Emil Skamene and Martin Olivier and Serge Jothy and Philippe Gros},
  journal={The Journal of Experimental Medicine},
  year={1995},
  volume={182},
  pages={655 - 666}
}
In mice, natural resistance or susceptibility to infection with intracellular parasites is determined by a locus or group of loci on chromosome 1, designated Bcg, Lsh, and Ity, which controls early microbial replication in reticuloendothelial organs. We have identified by positional cloning a candidate gene for Bcg, Nramp1, which codes for a novel macrophage-specific membrane transport protein. We have created a mouse mutant bearing a null allele at Nramp1, and we have analyzed the effect of… CONTINUE READING

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