The Italian breast cancer prevention trial with tamoxifen: findings and new perspectives.

@article{Guerrierigonzaga2001TheIB,
  title={The Italian breast cancer prevention trial with tamoxifen: findings and new perspectives.},
  author={Aliana Guerrieri-gonzaga and A. Galli and Nicole Rotmensz and Andrea U. Decensi},
  journal={Annals of the New York Academy of Sciences},
  year={2001},
  volume={949},
  pages={
          113-22
        }
}
The Italian Tamoxifen Prevention Study includes 5408 healthy hysterectomized women aged 35-70 years who have been randomized to 20 mg/day of tamoxifen or placebo for 5 years. After 46 months median follow-up, an increased risk of venous vascular events (38 women on tamoxifen vs. 18 women on placebo, P = 0.0053), mainly consisting of superficial phlebitis, has been observed and 41 breast cancers have occurred (19 on tamoxifen vs. 22 on placebo, P = 0.64). However, subgroup analyses indicated a… CONTINUE READING
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