The Irony of Humanization: Alemtuzumab, the First, But One of the Most Immunogenic, Humanized Monoclonal Antibodies

@article{Baker2020TheIO,
  title={The Irony of Humanization: Alemtuzumab, the First, But One of the Most Immunogenic, Humanized Monoclonal Antibodies},
  author={D. Baker and Liaqat Ali and G. Saxena and G. Pryce and M. Jones and K. Schmierer and G. Giovannoni and S. Gnanapavan and Kathleen C. Munger and L. Samkoff and A. Goodman and Angray S. Kang},
  journal={Frontiers in Immunology},
  year={2020},
  volume={11}
}
Alemtuzumab was designed to reduce the immunogenicity of the parent CD52-specific rat immunoglobulin. Although originally marketed for use in cancer (Mabcampath®), alemtuzumab is currently licensed and formulated for the treatment of relapsing multiple sclerosis (Lemtrada®). Perhaps due to its history as the first humanized antibody, the potential of immunogenicity of the molecule has been considered inconsequential, and anti-drug antibodies (ADA) responses were similarly reported as being… Expand
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