The IpaC Carboxyterminal Effector Domain Mediates Src-Dependent Actin Polymerization during Shigella Invasion of Epithelial Cells

@article{Mounier2009TheIC,
  title={The IpaC Carboxyterminal Effector Domain Mediates Src-Dependent Actin Polymerization during Shigella Invasion of Epithelial Cells},
  author={Jo{\"e}lle Mounier and Michel Robert Popoff and Jost Enninga and Margaret C Frame and Philippe J Sansonetti and Guy Tran Van Nhieu},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={242 - 248}
}
Shigella, the causative agent of bacillary dysentery, invades epithelial cells by locally reorganizing the actin cytoskeleton. Shigella invasion requires actin polymerization dependent on the Src tyrosine kinase and a functional bacterial type III secretion (T3S) apparatus. Using dynamic as well as immunofluorescence microscopy, we show that the T3S translocon component IpaC allows the recruitment of the Src kinase required for actin polymerization at bacterial entry sites during the initial… CONTINUE READING

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