The Ionizing Radiation-Induced Bystander Effect: Evidence, Mechanism, and Significance

@inproceedings{Azzam2013TheIR,
  title={The Ionizing Radiation-Induced Bystander Effect: Evidence, Mechanism, and Significance},
  author={Edouard I. Azzam and Sonia M. de Toledo and Andrew L Harris and Vladimir N. Ivanov and Hongning Zhou and Sally A. Amundson and Howard B. Lieberman and Tom K. Hei},
  year={2013}
}
It has long been considered that the important biological effects of ­ionizing radiation are a direct consequence of unrepaired or misrepaired DNA damage occurring in the irradiated cells. It was presumed that no effect would occur in cells in the population that receive no direct radiation exposure. However, in vitro evidence generated over the past two decades has indicated that non-targeted cells in irradiated cell cultures also experience significant biochemical and phenotypic changes that… CONTINUE READING
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