The Involvement of the CD40-CD40L Pathway in Activated Platelet-Induced Changes in HUVEC COX-2 and PPARα Expression

@article{Wu2011TheIO,
  title={The Involvement of the CD40-CD40L Pathway in Activated Platelet-Induced Changes in HUVEC COX-2 and PPARα Expression},
  author={Yan-qing Wu and Xiao-shu Chen and Jun-bing Chai},
  journal={Inflammation},
  year={2011},
  volume={35},
  pages={1184-1190}
}
We aim to determine the extent of the CD40-CD40L pathway involvement in activated platelet-induced changes in human umbilical endothelial cells (HUVECs). Activated platelets were co-incubated with HUVECs in the presence or absence of CD40LmAb. HUVECs were also directly stimulated with rhCD40L. HUVEC endothelial cyclooxygenase 2 (COX-2) and peroxisome proliferator-activated receptor alpha (PPARα) expression was then assessed. To estimate COX-2 activity, PGE2 concentration was determined. PPAR… CONTINUE READING