The Intravenous Use of Cocaine; Report of a Case

@article{HarrisonTheIU,
  title={The Intravenous Use of Cocaine; Report of a Case},
  author={P. W. Harrison},
  journal={The New England Journal of Medicine},
  volume={164},
  pages={151-151}
}
5 Citations

Topics from this paper

Cocaine analgesia: An in vivo structure-activity study
TLDR
Hot plate testing of rats was performed to determine the optimal analgesic doses of intracerebroventricularly administered cocaine, significant cocaine metabolites, and selected structurally similar molecules, and findings suggest that a hydrophobic group at the C-3 attached carbon is critical for analgesia. Expand
The effect of systemic cocaine on the responses to noxious stimuli and spontaneous activity of medial bulboreticular projection neurons
TLDR
Findings provide direct evidence that cocaine, in doses that are antinociceptive for the rat, affects both unit responses to noxious stimuli and the spontaneous activity of caudally and rostrally projecting bulboreticular neurons over a time course that parallels the behavioral ant inociception. Expand
Cocaine: evidence for supraspinal, dopamine-mediated, non-opiate analgesia
TLDR
It is concluded that cocaine is a supraspinally acting, dopamine-mediated, non-opiate analgesic in the rat. Expand
The effect of systemic cocaine on spinal nociceptive reflex activity in the rat
TLDR
It is suggested that systemic cocaine, in doses analgesic for the rat, does not suppress spinal nociceptive reflexes and the neurogenic extravasation response to antidromic cutaneous C-fiber stimulation was unaffected. Expand
Cocaine: 1884–1974
Cocaine, because of its unique properties as a local anesthetic, is still widely used in medicine some one hundred years after its introduction to Europe as a panacea. Karl Koller’s discovery of theExpand