The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis

@article{Winkler2020TheIM,
  title={The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis},
  author={E. S. Winkler and Swathi Shrihari and Barry L. Hykes and Scott A Handley and M. Diamond},
  journal={Cell},
  year={2020}
}
  • E. S. Winkler, Swathi Shrihari, +2 authors M. Diamond
  • Published 2020
  • Medicine
  • Cell
  • Chikungunya virus (CHIKV), an emerging alphavirus, has infected millions of people. However, the factors modulating disease outcome remain poorly understood. Here, we show in germ-free mice or in oral antibiotic-treated conventionally housed mice with depleted intestinal microbiomes that greater CHIKV infection and spread occurs within 1 day of virus inoculation. Alteration of the microbiome alters TLR7-MyD88 signaling in plasmacytoid dendritic cells (pDCs) and blunts systemic production of… CONTINUE READING