The Intestinal Heme Transporter Revealed

@article{Rouault2005TheIH,
  title={The Intestinal Heme Transporter Revealed},
  author={T. Rouault},
  journal={Cell},
  year={2005},
  volume={122},
  pages={649-651}
}
The iron-containing porphyrin heme provides a rich source of dietary iron for mammals. The fact that animals can derive iron from heme implies the existence of a transporter that would transport heme from the gut lumen into intestinal epithelial cells. In this issue of Cell, Shayeghi, McKie, and co-workers (Shayeghi et al., 2005) now describe a heme transporter that is expressed in the apical region of epithelial cells in the mouse duodenum. Their identification of heme carrier protein 1 (HCP1… Expand
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