Control of intracellular heme levels: heme transporters and heme oxygenases.
- BiologyBiochimica et biophysica acta
The Effect of Calcium on Non-heme Iron Uptake, Efflux, and Transport in Intestinal-like Epithelial Cells (Caco-2 Cells)
- BiologyBiological Trace Element Research
The effect of higher calcium to iron molar ratios on the efflux of non-heme iron may be large enough to explain results from human studies.
Non-heme Iron as Ferrous Sulfate Does Not Interact with Heme Iron Absorption in Humans
- MedicineBiological Trace Element Research
Evidence is reported that heme and non-heme iron as ferrous sulfate does not compete for absorption, when both iron forms are ingested on an empty stomach.
Cloning and characterization of a novel periplasmic heme-transport protein from the human pathogen Pseudomonas aeruginosa
- BiologyJBIC Journal of Biological Inorganic Chemistry
Mutagenesis studies support Y71–heme iron ligation in the recombinant HTP and a tyrosine residue (Y71) is highly conserved in the HTP sequences, which is likely an axial heme ligand in HTPs.
Mechanisms of cell protection by heme oxygenase-1.
- BiologyAnnual review of pharmacology and toxicology
The mechanism underlying this cytoprotective effect relies on the ability of HO-1 to catabolize free heme and prevent it from sensitizing cells to undergo programmed cell death.
rain Iron Metabolism racey
The possibility thatIron accumulations, which are often thought to facilitate free radical generation and oxidative damage, may contain insoluble iron that is unavailable for cellular use, and the pathology associated with iron accumulations may result from functional iron deficiency in some diseases is considered.
A general map of iron metabolism and tissue-specific subnetworks.
- BiologyMolecular bioSystems
This work constructs iron networks for specific tissues and cells that are fundamental to maintaining body iron homeostasis and includes subnetworks for cells of the intestine and liver, tissues important in iron uptake and storage, respectively, as well as the reticulocyte and macrophage, key cells in iron utilization and recycling.
Calcium does not inhibit the absorption of 5 milligrams of nonheme or heme iron at doses less than 800 milligrams in nonpregnant women.
- Chemistry, MedicineThe Journal of nutrition
An isolated effect of calcium (as chloride) on absorption of 5 mg of iron provided as nonheme (as sulfate) and heme ( as CRBC) iron was observed at doses higher than previously reported from single-meal studies.
SHOWING 1-10 OF 20 REFERENCES
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.
- BiologyMolecular cell
A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism*
- BiologyThe Journal of Biological Chemistry
Data indicate that MTP1 is an iron-regulated membrane-spanning protein that is involved in intracellular iron metabolism.
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
A new metal-ion transporter in the rat, DCT1, which has an unusually broad substrate range that includes Fe2+, Zn2+, Mn2+, Co2+, Cd2+, Cu2+, Ni2+ and Pb2+.
Rare causes of hereditary iron overload.
- BiologySeminars in hematology
Several rare iron loading conditions caused by genetic defects in some of the proteins involved in iron metabolism are described, including iron overload characterized by iron accumulation in macrophages yet normal plasma iron levels.
Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization
It is reported that hepcidin bound to ferroportin in tissue culture cells, leading to decreased export of cellular iron and the posttranslational regulation of ferroports by hePCidin may complete a homeostatic loop.
Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells.
- BiologyAmerican journal of physiology. Cell physiology
It is demonstrated that MNK relocalizes from the Golgi to the basolateral (BL) membrane under elevated copper conditions and a dileucine motif proximal to the COOH terminus of MNK that was critical for correctly targeting the protein to the BL membrane and a putative PDZ target motif that was required for localization at theBL membrane in elevated copper.
Iron homeostasis: insights from genetics and animal models
- BiologyNature Reviews Genetics
The animal models described in this review offer valuable tools for investigating iron homeostasis in vivo and complementing the genomic strategy, targeted mutagenesis in mice has produced new models of human iron diseases.
A receptor domain controls the intracellular sorting of the ferrichrome transporter, ARN1
- BiologyThe EMBO journal
It is proposed that the carboxyl terminus of Arn1p contains a receptor domain that controls the intracellular trafficking of the transporter, and this site has an affinity similar to the KT for transport, but the second site has a much higher affinity.