The Intestinal Chemokine Thymus-expressed Chemokine (CCL25) Attracts IgA Antibody-secreting Cells

@article{Bowman2002TheIC,
  title={The Intestinal Chemokine Thymus-expressed Chemokine (CCL25) Attracts IgA Antibody-secreting Cells},
  author={Edward P. Bowman and Nelly A. Kuklin and Kenneth R. Youngman and Nicole H. Lazarus and Eric J. Kunkel and Junliang Pan and Harry B. Greenberg and Eugene C. Butcher},
  journal={The Journal of Experimental Medicine},
  year={2002},
  volume={195},
  pages={269 - 275}
}
Immunoglobulin A (IgA) provides protection against pathogens at mucosal surfaces. Chemotactic responses have been hypothesized to target IgA plasma cells involved in mucosal immune responses. We show here that thymus-expressed chemokine (TECK, CCL25) is a potent and selective chemoattractant for IgA antibody-secreting cells (ASC), efficiently recruiting IgA-producing cells from spleen, Peyer's patches, and mesenteric lymph node. Cells secreting IgA antibody in response to rotavirus, an… Expand
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