The Intestinal Anti-inflammatory Activity of UR-12746S on Reactivated Experimental Colitis Is Mediated Through Downregulation of Cytokine Production

@article{Glvez2003TheIA,
  title={The Intestinal Anti-inflammatory Activity of UR-12746S on Reactivated Experimental Colitis Is Mediated Through Downregulation of Cytokine Production},
  author={Julio G{\'a}lvez and M. V. Ostos Garrido and Mar{\'i}a Elena Rodr{\'i}guez-Cabezas and Isabel Ramis and Ferm{\'i}n S{\'a}nchez de Medina and Manuel Merlos and Antonio Zarzuelo},
  journal={Inflammatory Bowel Diseases},
  year={2003},
  volume={9},
  pages={363-371}
}
BackgroundUR-12746S (dersalazine sodium) is cleaved by colonic bacteria delivering the PAF antagonist UR-12715 and 5-ASA. This study describes the anti-inflammatory activity of UR-12746S in an experimental model of reactivated colitis and its effects on cytokine production. MethodsRats were initially rendered colitic by a colonic instillation of 10 mg of trinitrobenzenesulphonic acid (TNBS) dissolved in 0.25 ml of 50 % ethanol, and colitis was reactivated two weeks after by a second… 
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