The Intersection of NO and H2S: Persulfides Generate NO from Nitrite through Polysulfide Formation.

  title={The Intersection of NO and H2S: Persulfides Generate NO from Nitrite through Polysulfide Formation.},
  author={T. S. Bailey and Hillary A. Henthorn and Michael D Pluth},
  journal={Inorganic chemistry},
  volume={55 24},
  • T. S. Bailey, Hillary A. Henthorn, Michael D Pluth
  • Published 2016
  • Chemistry, Medicine
  • Inorganic chemistry
  • Hydrogen sulfide (H2S) and nitric oxide (NO) are important biosignaling molecules, and their biochemistries are increasingly recognized to be intertwined. Persulfides are an oxidized product of biological H2S and have emerged as important species involved in the biological action of reactive sulfur species. Using isolated persulfides, we employed a combination of experimental and computational methods to investigate the contribution of persulfides to H2S/NO crosstalk. Our studies demonstrate… CONTINUE READING
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