The Intersectin 2 Adaptor Links Wiskott Aldrich Syndrome Protein (WASp)-mediated Actin Polymerization to T Cell Antigen Receptor Endocytosis

@article{McGavin2001TheI2,
  title={The Intersectin 2 Adaptor Links Wiskott Aldrich Syndrome Protein (WASp)-mediated Actin Polymerization to T Cell Antigen Receptor Endocytosis},
  author={Mary K.H. McGavin and Karen Badour and Lynne A. Hardy and Terrance J Kubiseski and Jinyi Zhang and Katherine Anne Siminovitch},
  journal={The Journal of Experimental Medicine},
  year={2001},
  volume={194},
  pages={1777 - 1787}
}
Induction of T cell antigen receptor (TCR) endocytosis has a significant impact on TCR signaling and T cell behavior, but the molecular interactions coordinating internalization of the activated TCR are poorly understood. Previously we have shown that TCR endocytosis is regulated by the Wiskott Aldrich Syndrome protein (WASp), a cytosolic effector which, upon interaction with the cdc42 Rho GTPase, couples TCR engagement to Arp 2/3 complex-mediated actin polymerization. Here we report that WASp… CONTINUE READING
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