The Interplay between the Escherichia coli Rho Guanine Nucleotide Exchange Factor Effectors and the Mammalian RhoGEF Inhibitor EspH

@inproceedings{Wong2012TheIB,
  title={The Interplay between the Escherichia coli Rho Guanine Nucleotide Exchange Factor Effectors and the Mammalian RhoGEF Inhibitor EspH},
  author={Alexander R. C. Wong and Abigail Clements and Beno{\^i}t Raymond and Valerie F Crepin and Gad Frankel},
  booktitle={mBio},
  year={2012}
}
UNLABELLED Rho GTPases are important regulators of many cellular processes. Subversion of Rho GTPases is a common infection strategy employed by many important human pathogens. Enteropathogenic Escherichia coli and enterohemorrhagic Escherichia coli (EPEC and EHEC) translocate the effector EspH, which inactivates mammalian Rho guanine exchange factors (GEFs), as well as Map, EspT, and EspM2, which, by mimicking mammalian RhoGEFs, activate Rho GTPases. In this study we found that EspH induces… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Desmosome Disruption by Enteropathogenic E coli

Cellular and molecular gastroenterology and hepatology • 2018
View 2 Excerpts

Intestinal cell migration damage induced by enteropathogenic Escherichia coli strains

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas • 2018

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics

Z Huang
Nat. Struct. Mol. Biol • 2009
View 11 Excerpts
Highly Influenced

Focal adhesion kinase: in command and control of cell motility

Nature Reviews Molecular Cell Biology • 2005
View 4 Excerpts
Highly Influenced

EspM2 is a RhoA guanine nucleotide exchange factor

Cellular microbiology • 2010
View 1 Excerpt

NleH effectors interact with Bax inhibitor-1 to block apoptosis during enteropathogenic Escherichia coli infection.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 15 Excerpts

Similar Papers

Loading similar papers…