The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First?

@inproceedings{Choukrallah2014TheIB,
  title={The Interplay between Chromatin and Transcription Factor Networks during B Cell Development: Who Pulls the Trigger First?},
  author={Mohamed Amin Choukrallah and Patrick D. Matthias},
  booktitle={Front. Immunol.},
  year={2014}
}
All mature blood cells derive from hematopoietic stem cells through gradual restriction of their cell fate potential and acquisition of specialized functions. Lineage specification and cell commitment require the establishment of specific transcriptional programs involving the activation of lineage-specific genes and the repression of lineage-inappropriate genes. This process requires the concerted action of transcription factors (TFs) and epigenetic modifying enzymes. Within the hematopoietic… CONTINUE READING
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