The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer.

@article{Governa2017TheIB,
  title={The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer.},
  author={Valeria Governa and Emanuele Trella and Valentina Mele and Luigi Tornillo and Francesca Amicarella and Eleonora Cremonesi and Manuele Giuseppe Muraro and Hui Xu and Raoul A. Droeser and Silvio Raffael D{\"a}ster and Martin Bolli and Raffaele Rosso and Daniel Oertli and Serenella Eppenberger-Castori and Luigi Maria Terracciano and Giandomenica Iezzi and Giulio Cesare Spagnoli},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2017},
  volume={23 14},
  pages={
          3847-3858
        }
}
Purpose: Tumor infiltration by different T lymphocyte subsets is known to be associated with favorable prognosis in colorectal cancer. Still debated is the role of innate immune system. We investigated clinical relevance, phenotypes, and functional features of colorectal cancer-infiltrating CD66b+ neutrophils and their crosstalk with CD8+ T cells.Experimental Design: CD66b+ and CD8+ cell infiltration was analyzed by IHC on a tissue microarray including >650 evaluable colorectal cancer samples… CONTINUE READING

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