The Interleukin-8 Pathway in Cancer

@article{Waugh2008TheIP,
  title={The Interleukin-8 Pathway in Cancer},
  author={David J. Waugh and Catherine Wilson},
  journal={Clinical Cancer Research},
  year={2008},
  volume={14},
  pages={6735 - 6741}
}
Interleukin-8 (IL-8) is a proinflammatory CXC chemokine associated with the promotion of neutrophil chemotaxis and degranulation. This chemokine activates multiple intracellular signaling pathways downstream of two cell-surface, G protein–coupled receptors (CXCR1 and CXCR2). Increased expression of IL-8 and/or its receptors has been characterized in cancer cells, endothelial cells, infiltrating neutrophils, and tumor-associated macrophages, suggesting that IL-8 may function as a significant… Expand

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