The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus Replication

@inproceedings{Chassey2013TheIO,
  title={The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus Replication},
  author={Beno{\^i}t de Chassey and A. Aublin-Gex and Alessia Ruggieri and Laur{\`e}ne Meyniel-Schicklin and Fabrine Pradezynski and Nathalie Davoust and T. Chantier and Lionel Tafforeau and P E Mangeot and Claire Ciancia and Laure Perrin-Cocon and Ralf Bartenschlager and Patrice Andr{\'e} and Vincent Lotteau},
  booktitle={PLoS pathogens},
  year={2013}
}
Influenza A NS1 and NS2 proteins are encoded by the RNA segment 8 of the viral genome. NS1 is a multifunctional protein and a virulence factor while NS2 is involved in nuclear export of viral ribonucleoprotein complexes. A yeast two-hybrid screening strategy was used to identify host factors supporting NS1 and NS2 functions. More than 560 interactions between 79 cellular proteins and NS1 and NS2 proteins from 9 different influenza virus strains have been identified. These interacting proteins… CONTINUE READING
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