The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer

@inproceedings{Gunter2012TheIB,
  title={The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer},
  author={Jennifer H. Gunter and Amy Anne Lubik and Ian F. C. McKenzie and Michael N. Pollak and Colleen C. Nelson},
  booktitle={Advances in urology},
  year={2012}
}
An association between the metabolic syndrome and reduced testosterone levels has been identified, and a specific inverse relationship between insulin and testosterone levels suggests that an important metabolic crosstalk exists between these two hormonal axes; however, the mechanisms by which insulin and androgens may be reciprocally regulated are not well described. Androgen-dependant gene pathways regulate the growth and maintenance of both normal and malignant prostate tissue, and androgen… CONTINUE READING