The Interaction of thiol drugs and urine pH in the treatment of cystinuria.

Abstract

PURPOSE Pharmacological therapy for cystinuria consists of alkali salts to increase urine pH and thiol drugs to form soluble cysteine-drug complexes. The effect of alkalinizing urine on thiol drug activity has not been well studied. MATERIALS AND METHODS Urine samples were obtained from 5 healthy subjects and pH was adjusted (range 6.0 to 8.0) in each… (More)
DOI: 10.1016/j.juro.2012.12.031

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