The Interaction of Vinculin with Actin

@inproceedings{Golji2013TheIO,
  title={The Interaction of Vinculin with Actin},
  author={Javad Golji and Mohammad R. K. Mofrad},
  booktitle={PLoS Computational Biology},
  year={2013}
}
Vinculin can interact with F-actin both in recruitment of actin filaments to the growing focal adhesions and also in capping of actin filaments to regulate actin dynamics. Using molecular dynamics, both interactions are simulated using different vinculin conformations. Vinculin is simulated either with only its vinculin tail domain (Vt), with all residues in its closed conformation, with all residues in an open I conformation, and with all residues in an open II conformation. The open I… CONTINUE READING

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