The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

@inproceedings{Wang2013TheIO,
  title={The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair},
  author={Hailong Wang and Linda Zhixia Shi and Catherine Chiu Lan Wong and Xuemei Han and Patty Yi-Hwa Hwang and Lan N. Truong and Qingyuan Zhu and Zhengping Shao and David J. Chen and Michael W. Berns and John R. Yates and Longchuan Chen and Xiaohua Wu},
  booktitle={PLoS genetics},
  year={2013}
}
CtIP plays an important role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair and interacts with Nbs1 and BRCA1, which are linked to Nijmegen breakage syndrome (NBS) and familial breast cancer, respectively. We identified new CDK phosphorylation sites on CtIP and found that phosphorylation of these newly identified CDK sites induces association of CtIP with the N-terminus FHA and BRCT domains of Nbs1. We further showed that these CDK-dependent phosphorylation… CONTINUE READING
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