The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway

@inproceedings{Talos2012TheIB,
  title={The Interaction between Early Life Epilepsy and Autistic-Like Behavioral Consequences: A Role for the Mammalian Target of Rapamycin (mTOR) Pathway},
  author={Delia Talos and Hongyu Sun and Xiangping Zhou and Erin Fitzgerald and Michele C. Jackson and Peter H. M. Klein and Victor J. Lan and Annelise Joseph and Frances E. Jensen},
  booktitle={PloS one},
  year={2012}
}
Early life seizures can result in chronic epilepsy, cognitive deficits and behavioral changes such as autism, and conversely epilepsy is common in autistic children. We hypothesized that during early brain development, seizures could alter regulators of synaptic development and underlie the interaction between epilepsy and autism. The mammalian Target of Rapamycin (mTOR) modulates protein translation and is dysregulated in Tuberous Sclerosis Complex, a disorder characterized by epilepsy and… CONTINUE READING
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