• Corpus ID: 21442230

The Integrative Treatment of Lyme Disease

@inproceedings{Bock2012TheIT,
  title={The Integrative Treatment of Lyme Disease},
  author={Steven Bock},
  year={2012}
}
Picture this scenario: You have a patient who started feeling fatigued, a kind of fatigue she had never felt before. Various joint started aching in different places, starting with the big joints (hips, knees), elbows, ankles, fingers and toes. She complains of headaches and pain in the back of the neck. She has problems remembering names or retrieving thoughts. She has no history of arthritis, and no personal or family history of depression. 
Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Intractable Fatigue in Western Blot-Positive ‘Chronic Lyme Disease’ Patients: Preliminary Report
TLDR
Analysis of subcategories of fatigue indicated that there were significant improvements in the ability to complete tasks and activities as well assignificant improvements in mood and cognitive abilities.

References

SHOWING 1-10 OF 14 REFERENCES
ASSOCIATION OF CHRONIC LYME ARTHRITIS WITH HLA‐DR4 and HLA‐DR2 ALLELES
TLDR
Particular Class II major histocompatibility genes determine a host immune response to B. burgdorferi that results in chronic arthritis and lack of response to antibiotics, and appear to act as independent, dominant markers of susceptibility.
Invasion of the central nervous system by Borrelia burgdorferi in acute disseminated infection.
TLDR
B burgdorferi can invade the CNS early in the course of infection, and careful consideration should be given to choosing antibiotics that achieve adequate CSF levels in patients with disseminated infection.
Survival of Borrelia burgdorferi in antibiotically treated patients with lyme borreliosis
TLDR
It is concluded that early stage of the disease as well as chronic Lyme disease with persistence of Borrelia burgdorferi after antibiotic therapy cannot be excluded when the serum is negative for antibodies against B. burgdorFERi.
Fibroblasts protect the Lyme disease spirochete, Borrelia burgdorferi, from ceftriaxone in vitro.
TLDR
Several eukaryotic cell types provide the Lyme disease spirochete with a protective environment contributing to its long-term survival, indicating that it resists eradication by host defense mechanisms and antibiotics.
Borrelia burgdorferi-infected, interleukin-6-deficient mice have decreased Th2 responses and increased lyme arthritis.
TLDR
The results extend previous in vitro observations by demonstrating an in vivo role for IL-6 in the differentiation of CD4 T cells toward a Th2 phenotype and further show thatCD4 T cell responses influence murine Lyme arthritis.
Lyme borreliosis
In vitro evidence for lymphocytic membrane cloaking by Borrelia burgdorferi
    Multivariable analysis of 160 patients with Lyme disease
    • National Institute of Allergic and Infectious Disease , NIH fact Sheet
    In vitro evidence for lymphocytic membrane cloaking by Borrelia burgdorferi
    • Lyme Disease Foundation, Scientific Conference,
    • 1998
    Antigen detection of Borrelia burgdorferi in urine
    • Lyme disease conference , April 19 ,
    • 1996
    ...
    ...