The Integrated Use of Pharmacokinetic and Pharmacodynamic Models for the Definition of Breakpoints

@article{Stass2005TheIU,
  title={The Integrated Use of Pharmacokinetic and Pharmacodynamic Models for the Definition of Breakpoints},
  author={Heino Stass and Axel A H Dalhoff},
  journal={Infection},
  year={2005},
  volume={33},
  pages={29-35}
}
For fluoroquinolones AUC/MIC ratios are known to correlate with clinical outcomes for patients suffering from respiratory tract infections (RTI) and complicated skin and skin structure infections (cSSSI). This paper describes the results of a population PK/PD analysis followed by Monte Carlo simulations to estimate clinical outcome and the microbiological breakpoints for a 400 mg once-daily moxifloxacin (MFX) treatment schedule. Based on PK data from 416 subjects, a non-compartmental population… CONTINUE READING

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