The Insulin Receptor Substrate IRSp53 Links Postsynaptic shank1 to the Small G-Protein cdc42

@article{Soltau2002TheIR,
  title={The Insulin Receptor Substrate IRSp53 Links Postsynaptic shank1 to the Small G-Protein cdc42},
  author={Michaela Soltau and Dietmar Richter and Hans‐J{\"u}rgen Kreienkamp},
  journal={Molecular and Cellular Neuroscience},
  year={2002},
  volume={21},
  pages={575-583}
}
The multidomain shank/ProSAP/SSTRIP proteins are major scaffold proteins in glutamatergic synapses in the mammalian brain; expression of shank1/SSTRIP in hippocampal neurons induces morphological changes in dendritic spines, suggesting that shank1 is involved in synapse formation and activity-dependent changes of synaptic structure. Using part of the proline-rich region of shank1 in a yeast two hybrid screen, we identified the insulin receptor substrate IRSp53 as an interaction partner. Overlay… 
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Immunoprecipitation and immunocytochemistry experiments demonstrate that the interaction occurs at postsynaptic sites in the brain and IRSp53 is capable of inducing the formation of a triple complex (shank1/IRSp53/PSD‐95).
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TLDR
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TLDR
A novel interaction between Shank andβPIX, a guanine nucleotide exchange factor for the Rac1 and Cdc42 small GTPases, is reported, suggesting that Shank recruits βPIX and PAK to spines for the regulation of postsynaptic structure.
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TLDR
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Functional analysis of the insulin receptor substrate protein of 53 kDa (IRSp53) in the brain of Mus musculus (Linnaeus 1758)
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NMDA Receptor-Dependent Synaptic Translocation of Insulin Receptor Substrate p53 via Protein Kinase C Signaling
TLDR
It is reported here that IRSp53 is accumulated rapidly at the postsynaptic sites of cultured hippocampal neurons after glutamate or NMDA stimulation in an actin cytoskeleton-dependent manner, and this data suggest that IR sp53 is involved in NMDA receptor-linked synaptic plasticity via PKC signaling.
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells
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It is demonstrated that the Shank3 adaptor protein can mediate cellular signaling, and provide a molecular mechanism for the biological divergence between the Ret9 and Ret51 isoform.
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