The Inositol Trisphosphate Receptor Regulates a 50-Second Behavioral Rhythm in C. elegans

@article{Santo1999TheIT,
  title={The Inositol Trisphosphate Receptor Regulates a 50-Second Behavioral Rhythm in C. elegans},
  author={Paola Dal Santo and Mary A Logan and Andrew D. Chisholm and Erik M. Jorgensen},
  journal={Cell},
  year={1999},
  volume={98},
  pages={757-767}
}
The C. elegans defecation cycle is characterized by the contraction of three distinct sets of muscles every 50 s. Our data indicate that this cycle is regulated by periodic calcium release mediated by the inositol trisphosphate receptor (IP3 receptor). Mutations in the IP3 receptor slow down or eliminate the cycle, while overexpression speeds up the cycle. The IP3 receptor controls these periodic muscle contractions nonautonomously from the intestine. In the intestinal cells, calcium levels… CONTINUE READING
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