The Inositol Phosphatase SHIP-1 Inhibits NOD2-Induced NF-κB Activation by Disturbing the Interaction of XIAP with RIP2

@inproceedings{Cond2012TheIP,
  title={The Inositol Phosphatase SHIP-1 Inhibits NOD2-Induced NF-κB Activation by Disturbing the Interaction of XIAP with RIP2},
  author={Claude Cond{\'e} and Xavier Rambout and Marielle Lebrun and Aurore Lecat and Emmanuel Di Valentin and Franck Dequiedt and Jacques Piette and Geoffrey Gloire and Sylvie Legrand},
  booktitle={PloS one},
  year={2012}
}
SHIP-1 is an inositol phosphatase predominantly expressed in hematopoietic cells. Over the ten past years, SHIP-1 has been described as an important regulator of immune functions. Here, we characterize a new inhibitory function for SHIP-1 in NOD2 signaling. NOD2 is a crucial cytoplasmic bacterial sensor that activates proinflammatory and antimicrobial responses upon bacterial invasion. We observed that SHIP-1 decreases NOD2-induced NF-κB activation in macrophages. This negative regulation… CONTINUE READING
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XIAP mediates NOD signaling via interaction with RIP2.

Proceedings of the National Academy of Sciences of the United States of America • 2009
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