The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair

@inproceedings{Sarkar2010TheIC,
  title={The Ino80 chromatin-remodeling complex restores chromatin structure during UV DNA damage repair},
  author={Sovan Sarkar and Rhian Kiely and Peter J McHugh},
  booktitle={The Journal of cell biology},
  year={2010}
}
Chromatin structure is modulated during deoxyribonucleic acid excision repair, but how this is achieved is unclear. Loss of the yeast Ino80 chromatin-remodeling complex (Ino80-C) moderately sensitizes cells to ultraviolet (UV) light. In this paper, we show that INO80 acts in the same genetic pathway as nucleotide excision repair (NER) and that the Ino80-C contributes to efficient UV photoproduct removal in a region of high nucleosome occupancy. Moreover, Ino80 interacts with the early NER… CONTINUE READING

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