The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.

@article{Rapaport2015TheIR,
  title={The Inhibitory Receptor NKG2A Sustains Virus-Specific CD8⁺ T Cells in Response to a Lethal Poxvirus Infection.},
  author={Aaron S. Rapaport and Jill M Schriewer and Susan Gilfillan and Ed Hembrador and Ryan W. Crump and Beatrice F. M. Plougastel and Y Claire Wang and Gaelle Le Friec and Jian Feng Gao and Marina Cella and Hanspeter Pircher and Wayne M Yokoyama and R. Mark L. Buller and Marco Colonna},
  journal={Immunity},
  year={2015},
  volume={43 6},
  pages={1112-24}
}
CD8(+) T cells and NK cells protect from viral infections by killing virally infected cells and secreting interferon-γ. Several inhibitory receptors limit the magnitude and duration of these anti-viral responses. NKG2A, which is encoded by Klrc1, is a lectin-like inhibitory receptor that is expressed as a heterodimer with CD94 on NK cells and activated CD8(+) T cells. Previous studies on the impact of CD94/NKG2A heterodimers on anti-viral responses have yielded contrasting results and the in… CONTINUE READING
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Tissue-protective effects

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