The Inhibitory Effects of Ketamine and Pentobarbital on Substance P Receptors Expressed in Xenopus Oocytes

@article{Okamoto2003TheIE,
  title={The Inhibitory Effects of Ketamine and Pentobarbital on Substance P Receptors Expressed in Xenopus Oocytes},
  author={Takashi Okamoto and Kouichiro Minami and Yasuhito Uezono and Junichi Ogata and Munehiro Shiraishi and Akio Shigematsu and Yoichi Ueta},
  journal={Anesthesia \& Analgesia},
  year={2003},
  volume={97},
  pages={104-110}
}
Substance P receptors (SPR) modulate nociceptive transmission within the spinal cord. The effects of IV anesthetics on SPR are not clear. In this study, we investigated the effects of IV anesthetics on SPR expressed in Xenopus oocytes. We examined the effects of ketamine, pentobarbital, propofol, and tramadol on SP-induced Ca2+-activated Cl− currents mediated by SPR expressed in Xenopus oocytes using a whole-cell voltage clamp. Ketamine and pentobarbital inhibited the SPR-induced currents at… 

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